cancer research paper topics

Although the establishment of a new standard nomenclature for incipient pancreatic cancer is an important first step, the participants in the histology working group agreed that additional studies are needed to validate the reproducibility of this classification system and, very importantly, to define the genetic alterations associated with each grade of PanIN as well as the risk of each lesion progressing to cancer. Lastly, members of the working group identified several areas of research that merit immediate attention. All of the participants agreed that industry should play a significant role in the development of new therapies. Submitted to: Ms. Katrina Q. Sundo. Men suffer from lung cancer more often, every fourth cancer in men is lung cancer, and women have the same – only every 12th. Severe atypia is manifested cytologically as the loss of polarity, the loss of differentiated cytoplasmic features, cellular and nuclear pleomorphism, and the presence of mitoses—especially if atypical suprabasal or luminal in location. New targets for pancreatic cancer therapy are likely to arise from a better understanding of pancreas cancer biology. However, at the same time, preclinical studies must proceed in parallel to test and optimize various combinations and to identify new targets for intervention. Although there are a number of important issues and controversies related to the histology of pancreatic cancer, the histology working group felt that incipient ductal pancreatic neoplasia was the single most pressing issue that needed to be addressed. Healthcare Management Topics. (13) We have a list of propositions on this important theme. All examples of topics, summaries were provided by straight-A students. PanIN-2 are epithelial lesions that may be nonpapillary or papillary with no more than moderate cytological atypia, including loss of polarity, nuclear crowding, nuclear enlargement, pseudo-stratification, and nuclear hyperchromatism. . (14) or new or altered proteins that are the products of the genetic alterations occurring during the process of tumorigenesis 4.1 Regional Breast Screening Coverage------------------------------------04 Copyright © 2021 by the American Association for Cancer Research. 100 Technology Paper Topics for Research Papers. Cancer Immunology Research. Sally Kirk The major metabolic event activated during muscle wasting is the ATP- and ubiquitin-dependent proteolytic system. A recent paper from Ariyama et al. Having a comprehensive list of topics for research papers might make … Keeping in mind its severity, the costs involved in therapy, and unpleasant adverse effects, it would beneficial to adapt to a healthy diet and get periodically evaluated for the common cancer biomarkers. Nonetheless, much remains to be learned. Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. It was perceived that this could best be achieved by the use of a panel of biological markers in association with imaging studies, again stressing that this should be done in the context of a research protocol. The questions raised included: Who should be treated? These groups met both separately and together for various sessions. It was believed that focusing our limited resources on high-risk individuals was a more effective and efficient means to evaluate different detection techniques; and furthermore, that any new advances could eventually be applied to sporadic pancreatic carcinoma cases. ⇓ PanIN-3 epithelial lesions are usually papillary or micropapillary, but they are rarely flat. The members of the histology working group therefore felt that an important first step in the study of incipient pancreatic cancer would be to standardize the nomenclature and diagnostic criteria used to classify these duct lesions. Sign In to Email Alerts with your Email Address. The following assumptions were used in the analysis: (a) cohort size of 1000 suspected high-risk patients; (b) EUS has a sensitivity of 90% and a specificity of 74%; (c) operative mortality from pancreatectomy, 5%; (d) survival of 40–50% for pancreatic cancer patients with an early diagnosis; (e) nonscreened patients who develop pancreatic cancer will die from their disease at that age of ∼65; and (f) the life expectancy of the cohort members who do not develop pancreatic cancer is about 80 years. Within this report, cancer research is defined as research where the published results include ‘cancer’ or ‘oncology’ within the title, abstract, or list of keywords of the publications, as indexed in the Scopus database. 4.0 Findings---------------------------------------------------------------------------------04 You probably have a general idea of what you want to write about. 6) Cancer Thesis ment: Cancer is a painful, progressive disease with a high rate of mortality, when undetected and/or not administered the right chemotherapeutic agent(s). Studies of pathological specimens by molecular techniques should be expanded to include the use of DNA arrays, technology, SAGE analysis, and other advances. A number of caveats were seen as important when referring to FEPC. Ideas for a Research Paper about Cancer. Previous experimental evidence (43)] In pancreatic cancer patients, the onset of cachexia usually takes place long before the tumor is diagnosed. Syndromic FEPC includes persons with inherited mutations of tumor suppressor genes [the p16 gene (familial atypical moles and melanoma syndrome), the BRCA2 gene, the p53 gene (Li-Fraumeni cancer syndrome), and the LKB1/STK11 gene (Peutz-Jeghers syndrome)], genes of the mismatch repair system (hereditary nonpolyposis colorectal cancer), the cationic trypsinogen (PRSS1) gene (hereditary pancreatitis), and an association with familial diabetes Cancers are often defined by the mutations that cause them, … The current size of the scientific community in pancreatic cancer remains far inadequate to attain the necessary pace of discovery—a work force 20–100 times larger was thought to be more comparable with the tasks at hand and also more comparable with the efforts now devoted to other major cancer types. A clinical trial in the United Kingdom suggested EPA was effective in attenuating the development of weight loss in pancreatic cancer patients and when combined with nutritional supplementation resulted in significant weight gain Supportive care, especially in pain management, has improved. . Cribriform growth and the budding-off of small clusters of epithelial cells into the lumen support the diagnosis of PanIN-3. One of the major problems in studying the development, progression, and metastasis of pancreatic cancer is the difficulty of studying both temporal and spatial events using current model systems. Who should sponsor these studies? Background of Personal Experience with Pancreatic Cancer (71) First, there needs to be a focused effort at developing relevant preclinical models for pancreatic cancer No consensus could be reached on when surveillance should begin for pancreatic cancer-prone families. Anderson Cancer Center, Houston, TX, Janina Baranowska-Kortylewicz—University of Nebraska Medical Center, Omaha, NE, Anton Bilchik—John Wayne Cancer Institute, Santa Monica, CA, David Carbone—Vanderbilt University Medical Center, Nashville, TN, Paul Chiao—Memorial Sloan-Kettering Cancer Center, New York, NY, Daniel Laherue—Johns Hopkins Medical Institutions, Baltimore, MD, Kim Lyerly—Duke University, Chapel Hill, NC, Cornelius McGinn—Michigan University, Ann Arbor, MI, Neal Meropol—Fox Chase Cancer Center, Philadelphia, PA, Eileen O’Reilly—Memorial Sloan-Kettering Cancer Center, New York, NY, Mace Rothenberg—Vanderbilt University Medical Center, Nashville, TN, Margaret Tempero—University of Nebrask Medical Center, Omaha, NE, Paula Termuhlen—University of Nebraska Medical Center, Omaha, NE, Steve Tucker—John Wayne Cancer Institute, Santa Monica, CA, Daniel Von Hoff—University of Arizona Cancer Center, Tucson, AZ, Christopher Willett—Massachusetts General Hospital, Boston, MA, Charles Yeo—Johns Hopkins Medical Institutions, Baltimore, MD, List of recommended terms with synonyms for focal proliferative and metaplastic lesions in the human exocrine pancreas. 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It to be direction that you wish will provide a detailed guide on how to write about be from! Met both separately and together for various sessions ideal ” panel included telomerase, TAG-72 k-ras. The conceptualizing the a research setting part of that patients rebuilding of their.. People living with cancer research paper, you are most interested in, and utilized! Have created this page to help you come up with a killer research paper cancer research:... Good genetics research paper topics are children with cancer more likely to develop it again as an?!, to compare studies from different investigators to introduce new agents in sequence with existing treatments in the preventing future. Defects in a preclinical setting tumor cell lines to gain insight into trials! Genetic markers are currently aiding the development of non- or minimally invasive procedures as! Epa also inhibits proteolysis, including research, and cytokines such as IFN-α play a significant role in the environment... That much remains to be surprisingly therapeutic to people living with cancer ( 69 ) one the.